RSPO4 Back

R-spondin family, member 4

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NCBI Description of RSPO4
This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants.

Community Annotation of RSPO4 Add / Edit RSPO4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RSPO4 is highly significantly mutated in
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RSPO4 is significantly mutated in
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RSPO4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RSPO4