RRBP1 Back

ribosome binding protein 1 homolog 180kDa (dog)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RRBP1
This gene encodes a ribosome-binding protein of the endoplasmic reticulum (ER) membrane. Studies suggest that this gene plays a role in ER proliferation, secretory pathways and secretory cell differentiation, and mediation of ER-microtubule interactions. Alternative splicing has been observed and protein isoforms are characterized by regions of N-terminal decapeptide and C-terminal heptad repeats. Splicing of the tandem repeats results in variations in ribosome-binding affinity and secretory function. The full-length nature of variants which differ in repeat length has not been determined. Pseudogenes of this gene have been identified on chromosomes 3 and 7, and RRBP1 has been excluded as a candidate gene in the cause of Alagille syndrome, the result of a mutation in a nearby gene on chromosome 20p12.

Community Annotation of RRBP1 Add / Edit RRBP1: Annotations

No community annotations yet for RRBP1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RRBP1 is highly significantly mutated in
(none)
RRBP1 is significantly mutated in
(none)
RRBP1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RRBP1