RRAGB Back

Ras-related GTP binding B

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RRAGB
Ras-homologous GTPases constitute a large family of signal transducers that alternate between an activated, GTP-binding state and an inactivated, GDP-binding state. These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic GTPase activity. All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of which are phosphate-/magnesium-binding sites (PM1-PM3) and three of which are guanine nucleotide-binding sites (G1-G3). Transcript variants encoding distinct isoforms have been identified.

Community Annotation of RRAGB Add / Edit RRAGB: Annotations

No community annotations yet for RRAGB.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RRAGB is highly significantly mutated in
(none)
RRAGB is significantly mutated in
(none)
RRAGB is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RRAGB