RPS6KB2 Back

ribosomal protein S6 kinase, 70kDa, polypeptide 2

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NCBI Description of RPS6KB2

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.

Community Annotation of RPS6KB2 Add / Edit RPS6KB2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RPS6KB2 is highly significantly mutated in
RPS6KB2 is significantly mutated in
RPS6KB2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RPS6KB2