RPS6KA4 Back

ribosomal protein S6 kinase, 90kDa, polypeptide 4

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NCBI Description of RPS6KA4

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Community Annotation of RPS6KA4 Add / Edit RPS6KA4: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RPS6KA4 is highly significantly mutated in
RPS6KA4 is significantly mutated in
RPS6KA4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RPS6KA4