RPS6KA3 Back

ribosomal protein S6 kinase, 90kDa, polypeptide 3

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NCBI Description of RPS6KA3

This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome (CLS).

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RPS6KA3 is highly significantly mutated in
RPS6KA3 is significantly mutated in
RPS6KA3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RPS6KA3