RPS6KA1 Back

ribosomal protein S6 kinase, 90kDa, polypeptide 1

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NCBI Description of RPS6KA1
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signalling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RPS6KA1 is highly significantly mutated in
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RPS6KA1 is significantly mutated in
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RPS6KA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RPS6KA1