RPIA Back

ribose 5-phosphate isomerase A (ribose 5-phosphate epimerase)

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NCBI Description of RPIA
The protein encoded by this gene is an enzyme, which catalyzes the reversible conversion between ribose-5-phosphate and ribulose-5-phosphate in the pentose-phosphate pathway. This gene is highly conserved in most organisms. The enzyme plays an essential role in the carbohydrate metabolism. Mutations in this gene cause ribose 5-phosphate isomerase deficiency. A pseudogene is found on chromosome 18.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RPIA is highly significantly mutated in
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RPIA is significantly mutated in
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RPIA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RPIA