ROS1 Back

c-ros oncogene 1 , receptor tyrosine kinase

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NCBI Description of ROS1
This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ROS1 is highly significantly mutated in
(none)
ROS1 is significantly mutated in
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ROS1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ROS1