ROS1 Back

c-ros oncogene 1 , receptor tyrosine kinase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ROS1

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. The protein encoded by this gene is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.

Community Annotation of ROS1 Add / Edit ROS1: Annotations

No community annotations yet for ROS1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ROS1 is highly significantly mutated in
ROS1 is significantly mutated in
ROS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ROS1