RORB Back

RAR-related orphan receptor B

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NCBI Description of RORB
The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The specific functions of this protein are not known, but it has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation.

Community Annotation of RORB Add / Edit RORB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RORB is highly significantly mutated in
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RORB is significantly mutated in
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RORB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RORB