ROR1 Back

receptor tyrosine kinase-like orphan receptor 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of ROR1
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of ROR1 Add / Edit ROR1: Annotations

No community annotations yet for ROR1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ROR1 is highly significantly mutated in
(none)
ROR1 is significantly mutated in
(none)
ROR1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ROR1