ROCK2 Back

Rho-associated, coiled-coil containing protein kinase 2

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NCBI Description of ROCK2

The protein encoded by this gene is a serine/threonine kinase that regulates cytokinesis, smooth muscle contraction, the formation of actin stress fibers and focal adhesions, and the activation of the c-fos serum response element. This protein, which is an isozyme of ROCK1 is a target for the small GTPase Rho.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


ROCK2 is highly significantly mutated in
ROCK2 is significantly mutated in
ROCK2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for ROCK2