ROBO2 Back

roundabout, axon guidance receptor, homolog 2 (Drosophila)

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NCBI Description of ROBO2
This gene belongs to the ROBO family, part of the immunoglobulin superfamily proteins that are highly conserved from fly to human. The encoded protein is a receptor for SLIT2, molecules known to function in axon guidance and cell migration. Defects in this gene are the cause of vesicoureteral reflux type 2. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Community Annotation of ROBO2 Add / Edit ROBO2: Annotations

No community annotations yet for ROBO2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

ROBO2 is highly significantly mutated in
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ROBO2 is significantly mutated in
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ROBO2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for ROBO2