RNF6 Back

ring finger protein (C3H2C3 type) 6

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NCBI Description of RNF6

The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RNF6 is highly significantly mutated in
RNF6 is significantly mutated in
RNF6 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RNF6