RNF123 Back

ring finger protein 123

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NCBI Description of RNF123

The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1.

Community Annotation of RNF123 Add / Edit RNF123: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RNF123 is highly significantly mutated in
RNF123 is significantly mutated in
RNF123 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RNF123