ribonuclease H2, subunit C

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NCBI Description of RNASEH2C

This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RNASEH2C is highly significantly mutated in
RNASEH2C is significantly mutated in
RNASEH2C is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RNASEH2C