RIPK2 Back

receptor-interacting serine-threonine kinase 2

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NCBI Description of RIPK2

This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RIPK2 is highly significantly mutated in
RIPK2 is significantly mutated in
RIPK2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RIPK2