ras homolog gene family, member U

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RHOU

This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.

Community Annotation of RHOU Add / Edit RHOU: Annotations

No community annotations yet for RHOU.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RHOU is highly significantly mutated in
RHOU is significantly mutated in
RHOU is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RHOU