NCBI Description of RHOQ
|This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14.|
Community Annotation of RHOQ Add / Edit RHOQ: Annotations
No community annotations yet for RHOQ.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.