RHOG Back

ras homolog gene family, member G (rho G)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RHOG

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.

Community Annotation of RHOG Add / Edit RHOG: Annotations

No community annotations yet for RHOG.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RHOG is highly significantly mutated in
(none)
RHOG is significantly mutated in
(none)
RHOG is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for RHOG