Rho-related BTB domain containing 1

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NCBI Description of RHOBTB1

The protein encoded by this gene belongs to the Rho family of the small GTPase superfamily. It contains a GTPase domain, a proline-rich region, a tandem of 2 BTB (broad complex, tramtrack, and bric-a-brac) domains, and a conserved C-terminal region. The protein plays a role in small GTPase-mediated signal transduction and the organization of the actin filament system. Alternate splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RHOBTB1 is highly significantly mutated in
RHOBTB1 is significantly mutated in
RHOBTB1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RHOBTB1