RGS2 Back

regulator of G-protein signaling 2, 24kDa

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NCBI Description of RGS2
Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 2 belongs to this family. The protein acts as a mediator of myeloid differentiation and may play a role in leukemogenesis.

Community Annotation of RGS2 Add / Edit RGS2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RGS2 is highly significantly mutated in
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RGS2 is significantly mutated in
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RGS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RGS2