RGS11 Back

regulator of G-protein signaling 11

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NCBI Description of RGS11
The protein encoded by this gene belongs to the RGS (regulator of G protein signaling) family. Members of the RGS family act as GTPase-activating proteins on the alpha subunits of heterotrimeric, signal-transducing G proteins. This protein inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified.

Community Annotation of RGS11 Add / Edit RGS11: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RGS11 is highly significantly mutated in
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RGS11 is significantly mutated in
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RGS11 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RGS11