RFX4 Back

regulatory factor X, 4 (influences HLA class II expression)

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NCBI Description of RFX4
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RFX4 is highly significantly mutated in
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RFX4 is significantly mutated in
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RFX4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RFX4