RFX1 Back

regulatory factor X, 1 (influences HLA class II expression)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RFX1
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X2, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with RFX family members X2, X3, and X5, but not with X4. This protein binds to the X-boxes of MHC class II genes and is essential for their expression. Also, it can bind to an inverted repeat that is required for expression of hepatitis B virus genes.

Community Annotation of RFX1 Add / Edit RFX1: Annotations

No community annotations yet for RFX1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RFX1 is highly significantly mutated in
(none)
RFX1 is significantly mutated in
(none)
RFX1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RFX1