RFC1 Back

replication factor C (activator 1) 1, 145kDa

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RFC1

This gene encodes the large subunit of replication factor C, a five subunit DNA polymerase accessory protein, which is a DNA-dependent ATPase required for eukaryotic DNA replication and repair. The large subunit acts as an activator of DNA polymerases, binds to the 3' end of primers, and promotes coordinated synthesis of both strands. It may also have a role in telomere stability. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Community Annotation of RFC1 Add / Edit RFC1: Annotations

No community annotations yet for RFC1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RFC1 is highly significantly mutated in
RFC1 is significantly mutated in
RFC1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RFC1