REPS2 Back

RALBP1 associated Eps domain containing 2

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NCBI Description of REPS2
The product of this gene is part of a protein complex that regulates the endocytosis of growth factor receptors. The encoded protein directly interacts with a GTPase activating protein that functions downstream of the small G protein Ral. Its expression can negatively affect receptor internalization and inhibit growth factor signaling. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of REPS2 Add / Edit REPS2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

REPS2 is highly significantly mutated in
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REPS2 is significantly mutated in
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REPS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for REPS2