RCN1 Back

reticulocalbin 1, EF-hand calcium binding domain

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NCBI Description of RCN1
Reticulocalbin 1 is a calcium-binding protein located in the lumen of the ER. The protein contains six conserved regions with similarity to a high affinity Ca(+2)-binding motif, the EF-hand. High conservation of amino acid residues outside of these motifs, in comparison to mouse reticulocalbin, is consistent with a possible biochemical function besides that of calcium binding. In human endothelial and prostate cancer cell lines this protein localizes to the plasma membrane.

Community Annotation of RCN1 Add / Edit RCN1: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RCN1 is highly significantly mutated in
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RCN1 is significantly mutated in
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RCN1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RCN1