RCBTB1 Back

regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1

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NCBI Description of RCBTB1
This gene encodes a protein with an N-terminal RCC1 domain and a C-terminal BTB (broad complex, tramtrack and bric-a-brac) domain. In rat, over-expression of this gene in vascular smooth muscle cells induced cellular hypertrophy. In rat, the C-terminus of RCBTB1 interacts with the angiotensin II receptor-1A. In humans, this gene maps to a region of chromosome 13q that is frequently deleted in B-cell chronic lymphocytic leukemia and other lymphoid malignancies.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RCBTB1 is highly significantly mutated in
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RCBTB1 is significantly mutated in
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RCBTB1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RCBTB1