RCAN1 Back

regulator of calcineurin 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RCAN1
The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Community Annotation of RCAN1 Add / Edit RCAN1: Annotations

No community annotations yet for RCAN1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RCAN1 is highly significantly mutated in
(none)
RCAN1 is significantly mutated in
(none)
RCAN1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RCAN1