RBBP5 Back

retinoblastoma binding protein 5

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NCBI Description of RBBP5
This gene encodes a ubiquitously expressed nuclear protein which belongs to a highly conserved subfamily of WD-repeat proteins. The encoded protein binds directly to retinoblastoma protein, which regulates cell proliferation. It interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B. Three alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Community Annotation of RBBP5 Add / Edit RBBP5: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RBBP5 is highly significantly mutated in
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RBBP5 is significantly mutated in
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RBBP5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RBBP5