RASSF8 Back

Ras association (RalGDS/AF-6) domain family (N-terminal) member 8

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NCBI Description of RASSF8
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Community Annotation of RASSF8 Add / Edit RASSF8: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RASSF8 is highly significantly mutated in
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RASSF8 is significantly mutated in
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RASSF8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RASSF8