RASSF5 Back

Ras association (RalGDS/AF-6) domain family member 5

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NCBI Description of RASSF5
This gene is a member of the Ras association domain family. It functions as a tumor suppressor, and is inactivated in a variety of cancers. The encoded protein localizes to centrosomes and microtubules, and associates with the GTP-activated forms of Ras, Rap1, and several other Ras-like small GTPases. The protein regulates lymphocyte adhesion and suppresses cell growth in response to activated Rap1 or Ras. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RASSF5 is highly significantly mutated in
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RASSF5 is significantly mutated in
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RASSF5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RASSF5