Ras protein-specific guanine nucleotide-releasing factor 2

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NCBI Description of RASGRF2

RAS GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. This gene encodes a calcium-regulated nucleotide exchange factor activating both RAS and RAS-related protein, RAC1, through the exchange of bound GDP for GTP, thereby, coordinating the signaling of distinct mitogen-activated protein kinase pathways.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RASGRF2 is highly significantly mutated in
RASGRF2 is significantly mutated in
RASGRF2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RASGRF2