RASA2 Back

RAS p21 protein activator 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of RASA2
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member has a perinuclear localization and is an inositol 1,3,4,5-tetrakisphosphate-binding protein; a compound suggested to function as a second messenger.

Community Annotation of RASA2 Add / Edit RASA2: Annotations

No community annotations yet for RASA2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RASA2 is highly significantly mutated in
(none)
RASA2 is significantly mutated in
(none)
RASA2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RASA2