NCBI Description of RAPGEF1
|This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.|
Community Annotation of RAPGEF1 Add / Edit RAPGEF1: Annotations
No community annotations yet for RAPGEF1.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.