RAPGEF1 Back

Rap guanine nucleotide exchange factor (GEF) 1

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NCBI Description of RAPGEF1
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RAPGEF1 is highly significantly mutated in
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RAPGEF1 is significantly mutated in
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RAPGEF1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for RAPGEF1