RAP1GAP2 Back

RAP1 GTPase activating protein 2

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NCBI Description of RAP1GAP2

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of RAP1GAP2 Add / Edit RAP1GAP2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

RAP1GAP2 is highly significantly mutated in
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RAP1GAP2 is significantly mutated in
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RAP1GAP2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for RAP1GAP2