NCBI Description of RAP1A
|The product of this gene belongs to the family of RAS-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. The product of this gene counteracts the mitogenic function of RAS because it can interact with RAS GAPs and RAF in a competitive manner. Two transcript variants encoding the same protein have been identified for this gene.|
Community Annotation of RAP1A Add / Edit RAP1A: Annotations
No community annotations yet for RAP1A.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.