Rac GTPase activating protein 1

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NCBI Description of RACGAP1

The protein encoded by this gene belongs to the GTPase-activating protein (GAP) family. GAPs bind activated forms of Rho GTPases and stimulate GTP hydrolysis. Through this catalytic function, GAPs negatively regulate Rho-mediated signals. This protein plays a regulatory role in initiation of cytokinesis, controlling cell growth and differentiation of hematopoietic cells, regulating spermatogenesis, and in neuronal proliferation. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of RACGAP1 Add / Edit RACGAP1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


RACGAP1 is highly significantly mutated in
RACGAP1 is significantly mutated in
RACGAP1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for RACGAP1