QPRT Back

quinolinate phosphoribosyltransferase (nicotinate-nucleotide pyrophosphorylase (carboxylating))

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NCBI Description of QPRT
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

QPRT is highly significantly mutated in
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QPRT is significantly mutated in
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QPRT is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for QPRT