PYCR1 Back

pyrroline-5-carboxylate reductase 1

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NCBI Description of PYCR1
This gene encodes an enzyme that catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline. This enzyme may also play a physiologic role in the generation of NADP(+) in some cell types. The protein forms a homopolymer and localizes to the mitochondrion. Alternate splicing results in two transcript variants encoding different isoforms.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PYCR1 is highly significantly mutated in
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PYCR1 is significantly mutated in
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PYCR1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PYCR1