PXN Back

paxillin

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NCBI Description of PXN

This gene encodes a cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. These isoforms exhibit different expression pattern, and have different biochemical, as well as physiological properties (PMID:9054445).

Community Annotation of PXN Add / Edit PXN: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PXN is highly significantly mutated in
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PXN is significantly mutated in
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PXN is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for PXN