PVRL3 Back

poliovirus receptor-related 3

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NCBI Description of PVRL3
This gene encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. This gene plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants.

Community Annotation of PVRL3 Add / Edit PVRL3: Annotations

No community annotations yet for PVRL3.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PVRL3 is highly significantly mutated in
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PVRL3 is significantly mutated in
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PVRL3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PVRL3