PVR Back

poliovirus receptor

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NCBI Description of PVR
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PVR Add / Edit PVR: Annotations

No community annotations yet for PVR.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PVR is highly significantly mutated in
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PVR is significantly mutated in
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PVR is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PVR