PTTG1IP Back

pituitary tumor-transforming 1 interacting protein

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NCBI Description of PTTG1IP
The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PTTG1IP is highly significantly mutated in
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PTTG1IP is significantly mutated in
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PTTG1IP is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PTTG1IP