PTTG1 Back

pituitary tumor-transforming 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PTTG1

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Community Annotation of PTTG1 Add / Edit PTTG1: Annotations

No community annotations yet for PTTG1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PTTG1 is highly significantly mutated in
PTTG1 is significantly mutated in
PTTG1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PTTG1