PTP4A1 Back

protein tyrosine phosphatase type IVA, member 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of PTP4A1
The protein encoded by this gene belongs to a small class of prenylated protein tyrosine phosphatases (PTPs), which contains a PTP domain and a characteristic C-terminal prenylation motif. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. This tyrosine phosphatase is a nuclear protein, but may primarily associate with plasma membrane. The surface membrane association of this protein depends on its C-terminal prenylation. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which implicated its role in the tumorigenesis. Studies in rat suggested that this gene may be an immediate-early gene in mitogen-stimulated cells.

Community Annotation of PTP4A1 Add / Edit PTP4A1: Annotations

No community annotations yet for PTP4A1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PTP4A1 is highly significantly mutated in
(none)
PTP4A1 is significantly mutated in
(none)
PTP4A1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PTP4A1