PTGS2 Back

prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)

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NCBI Description of PTGS2
Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. This gene encodes the inducible isozyme. It is regulated by specific stimulatory events, suggesting that it is responsible for the prostanoid biosynthesis involved in inflammation and mitogenesis. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of PTGS2 Add / Edit PTGS2: Annotations

No community annotations yet for PTGS2.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PTGS2 is highly significantly mutated in
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PTGS2 is significantly mutated in
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PTGS2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PTGS2