PTGS1 Back

prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)

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NCBI Description of PTGS1

This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. The protein may promote cell proliferation during tumor progression. Alternative splicing results in multiple transcript variants.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


PTGS1 is highly significantly mutated in
PTGS1 is significantly mutated in
PTGS1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for PTGS1