PTGFR Back

prostaglandin F receptor (FP)

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NCBI Description of PTGFR
The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of PTGFR Add / Edit PTGFR: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

PTGFR is highly significantly mutated in
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PTGFR is significantly mutated in
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PTGFR is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for PTGFR